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Sulforaphane-rich cruciferous vegetables have been shown to modulate CYP3A4 activity and enhance aflatoxin B1 detoxification, which is particularly relevant for individuals with reduced-function CYP3A4 or GST/UGT variants.[ref][ref] On the conjugation side, phase II enzymes determine how quickly reactive mycotoxin intermediates are neutralized and excreted from the body

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Recently, GPX3 has been recognized as a novel regulator of insulin receptor expression, insulin receptor and GPX3 expression were positively correlated in mouse models of obesity and insulin resistance: By activating the transcription factor SP1, GPX3 promotes insulin receptor expression in 3T3-L1 preadipocytes and improves adipose tissue insulin sensitivity

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