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Key findings: Ipamorelin produced dose-dependent GH release comparable to GHRP-6 Unlike GHRP-6, ipamorelin did not stimulate ACTH or cortisol release, even at doses up to 200 times higher than the effective GH-releasing dose Ipamorelin did not significantly increase prolactin levels The GH response was specific and consistent, supporting its classification as the most selective GHRP identified at the time This study established the foundation for all subsequent ipamorelin research and remains one of the most frequently cited papers in the field

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Moreover, Genistein, by reduction of pro-inflammatory mediators (IL-6, tumor necrosis factor- (TNF-) and C-reactive protein (CRP)) in serum and intestine in alloxan-induced diabetic rats, reduces the damage of L-cells and leads to an increase in the expression and secretion of GLP-1[191]