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These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase

If a clinician is discussing alternatives, the relevant comparison is not just the sticker amount

The clinical significance of this added increase in serum creatinine relative to placebo is not known

For most people, an FDA-approved brand or oral option is now the safer path