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Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA

FIGURE 5 2.4.1 Vascular remodeling In DR, the RhoA/ROCK signaling pathway is activated by high glucose, which leads to endothelial dysfunction, breakdown of the blood-retinal barrier (BRB), and capillary leakage

They speculated that the peptide may have attracted the central and peripheral melanocortin pathways to accomplish this function

Moreover, free phenolic extract from rape BP possesses higher capabilities to defend body cells from aberrant melanogenesis than bound phenolic extract via the suppression of microphthalmia-associated transcription factor (MITF) and downregulation of cyclic adenosine monophosphate (cyclic adenosine monophosphate) while preventing the anti-tyrosinase and antioxidant pathways in vitro (22)

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