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These TRM cells exhibit high levels of CD122, the IL-15 receptor subunit.3437 This antibody has demonstrated disease reversal in mice, making it a promising therapeutic target.38 Recently, it has been shown that TRM survival depends on the uptake and metabolism of exogenous fatty acids, suggesting that a possible treatment could be the regulation of lipid metabolism, focused on the elimination of TRMs in peripheral tissues.39 Intrinsic melanocyte abnormalities and epidermal and dermal alterations in vitiligo skin Several in vitro and in vivo studies have demonstrated the presence of intrinsic abnormalities in vitiligo melanocytes characterized by increased susceptibility to pro-oxidant agents

La mayora de los casos de exantema por inhibidores del RFCE desarrolla una toxicidad de grado 1 2, slo en el 13 % de los pacientes de grado 3 y, de forma destacable, no se ha comunicado ningn caso de toxicidad cutnea con compromiso vital26

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Browning, L

At the molecular level, BPC-157 contains four proline residues in positions 3-6, creating a rigid structural motif that resists proteolytic degradation in physiological conditions