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In spite of their limitations, these studies are the first to demonstrate a capacity of exogenously administered NAC to reach the CNS

The people who tend to get the most out of it have a specific profile: Adults over 40 who are already doing the fundamentals well: strength training, adequate protein, sleep, stress management

Tang X, Li X, Zhang D, Han W

Though those are nearly always elevated in cases of B12 deficiency, there are rare cases of severe B12 deficiency manifesting with normal B12 levels in the blood, normal MMA levels, and normal homocysteine