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Beyond T2DM, the Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes trial is assessing whether GLP-1 RAs can meaningfully reduce MACE, HF hospitalizations, and other cardiovascular endpoints in patients with type 1 diabetes, a population generally underrepresented in cardiovascular prevention studies [66]

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In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]

GLP-1 treatment typically starts at $450 for a three-month supply, with additional options available at $750 for a 13-week supply

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