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The peptide was named after the protective adenosine 1 receptor on the surface of neurons, which gets activated by adenosine, a chemical made mostly in the brain by neuron-supporting glial cells in response to hyperexcitability

293299 Together these processes conspire to produce renal fibrosis and sustained hypertension and their associated means of reducing renal oxygenation (figure 1)

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For TB-500, the status is similar (Investigational New Drug in the US) with very limited human data