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Elevated ROS increases PRDX2 monomer formation, which causes TIMELESS-TIPIN dissociation from the replisome and replication slowdown, thereby inducing replication stress

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He says that studies have shown that up to 70% of MVD-affected dogs with only mild enlargement will never reach heart failure (Stage C), and so to start them on pimobendan becomes an unnecessary expense for the dogs' owners, which can be considerable, up to $1,000.00 per year