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Some prodrugs require specific enzymes or endogenous compounds for hydrolysis, such as the carboxylesterases including acetylcholinesterase, butyrylcholinesterase and arylesterase that are critically involved in the bioconversion of ester-based prodrugs into pharmacologically active forms (Liederer and Borchardt, 2006)

Biogerontology 14:231245

While the addition of allosteric SHP2 inhibitors to MEK1/2-, ERK1/2-, or RAS-targeted drugs yields synergism and potently delays resistance development, therapy failure still needs to be anticipated and inadvertently occurs even with these combination strategies

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Is the association between socioeconomic position and coronary heart disease stronger in women than in men