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Removal of bioactive GLP-1 is a consequence of N-terminal proteolysis catalyzed by dipeptidyl peptidase IV (DPP IV or DPP4)

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GHRPs (growth hormone-releasing peptides) like Ipamorelin are ghrelin mimetics that activate the GHS-R receptor, a different receptor pathway that also triggers GH release

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People receiving the infusion can experience infusion-related side effects, so the manufacturer recommends premedication (for at least the first five infusions) with an NSAID or acetaminophen, an antihistamine, and/or an antiemetic