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If an underlying primary pathology is responsible, what type of early process could be operating in the area of myelin degeneration that does not exhibit signatures of an autoimmune lymphocytic-driven mechanism, or any detectable infectious or other obvious etiology
Table 1 Examples of human diseases where a known abnormality (often genetic, but can be acquired) results in white matter pathology and secondary inflammation which can mimic MS
Real-Time PCR Total RNA was extracted from cells by acid guanidinium thiocyanate-phenol-chloroform extraction method, and complementary (c)DNA was synthesized using 1 g total RNA in a 20 L RT reaction mix containing 0.5 g/L of random primers, 0.1 mM dNTP, 0.1 M DTT and 5 first strand buffer
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