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It also remains unclear how weight loss observed in these randomized controlled trials will generalize to real-world populations, said Nick Stucky, MD, PhD, vice president of Truveta Research, practicing infectious diseases physician at Providence Portland Medical Center, and an author on the paper

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When to Worry: Red Flags That Need a Doctor Bottom line: Call your clinician the same day, or go to urgent care, if you experience blood in the stool, fever above 101F, signs of dehydration (dizziness, dark urine, dry mouth), severe abdominal pain, vomiting that prevents fluids for more than 12 hours, GI symptoms lasting more than 7 days without improvement, or sudden weight loss greater than 5% in a week