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Side effects of Methycobal Injection (Major & minor) Nausea and vomiting Diarrhea Decreased appetite (rare) Dizziness (rare) Headache (rare) Skin rash Chest pain and discomfort (rare) When not to use

Storage and handling Before reconstitution (powder) Storage : Refrigerate at 2-8C (36-46F) Shelf life : 2-3 years when properly stored Stability : Very stable as lyophilized powder Travel : Can survive room temperature for short periods (days) After reconstitution (liquid) Storage : Refrigerate immediately at 2-8C Shelf life : 28 days with bacteriostatic water Stability : Degrades over time, use within 28 days Travel : Keep cold (use cooler with ice packs) Light : Protect from direct light (store in box) Handling tips Always use clean technique Don't contaminate vial top Use new needle each time Don't freeze Don't shake vigorously Mark reconstitution date on vial Common mistakes with 5mg vials Using wrong water Mistake : Using sterile water instead of bacteriostatic water

Both share theoretical concerns about pancreatitis (rare) and gallbladder events (related to rapid weight loss)

Compared to normal aging and D-GAL-induced premature aging models, research on endothelial cell senescence induced by hypoxia under pathological conditions remains scarce

Renal failure, and on rare occasions pancreatitis, can occur as a complication