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The results imply that even residues not directly involved in the interaction may exhibit changes in their chemical environment if they are adjacent to residues crucial for the interaction or undergo conformational changes upon binding 39,40

These are, in effect, competing engineering goals, because the hydrophobic modifications that extend half-life can also promote aggregation

Immune surveillance constantly examines the body for abnormal cells then eliminates them before they progress to clinical disease

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Very small individuals (under 50kg) might start at the lower end of dose ranges