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This selective mechanism produces metabolic safety benefits that may make AOD-9604 appropriate for individuals who cannot tolerate or have contraindications to conventional growth hormone therapy

Instead, they are just monitored by the FDA for adverse effects reported after the supplement is already available for purchase

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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year