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Other, more indirect strategies have evolved to translate cAMP signals into changes in POMC gene expression involving a CREB/c-Fos/AP-1 signaling cascade activating POMC transcription via an activator protein-1 (AP-1) site in exon 1

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It seems that the reduced number of oocytes retrieved with age may be of less importance than the decline in oocyte quality

Temperature was kept at 37 C using a rectal thermometer-controlled heatpad (TCAT-2LV, Physitemp, USA)