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| Frequently asked questions | Take home message Mounjaro (tirzepatide) is significantly more effective for weight loss and blood sugar control than Rybelsus (oral semaglutide) based on available clinical evidence

Over 26 weeks, including a dose-escalation period of up to 6 weeks, researchers observed mean percentage weight reductions of 6.0% to 10.8% across the cagrilintide dose groups compared to just 3.0% with placebo

However, this meta-analysis included only one RCT 43 and one case-control study 51 for GLP-1RAs (but not the more recent semaglutide) 41

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