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Federal legislation has also been proposed to allow Medicare to cover weight loss drugs as well as other therapy options for the treatment of obesity (e.g., counseling with a dietitian)

Practitioners hesitancy to start new medications due to perceived titration complexity, incomplete understanding of drug interactions, and uncertainty of monitoring tools and goals of care, coupled with a belief that GLP-1R agonists requiring subcutaneous injections would not be well received by patients are major barriers to optimal use

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The question of whether GLP-1 receptor agonists might increase pancreatic cancer risk emerged from preclinical animal studies and early post-marketing surveillance reports