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134 Aged mice show a decrease in the reconstitution capability of their hematopoietic stem cells (HSCs), correlating with an increase in DNA damage 135,136 and with an increase in the levels of senescence effectors, such as p16INK4a

In addition, berberine can properly restore the levels of 3-nitrotyrosine (3-NT), COX 2, glial fibrillary acidic protein (GFAP), and sirtuin 1 in the hippocampus (Sadraie et al., 2019)

Feeling fatigued or burned out Are practicing a vegetarian or vegan diet Have a history of anemia or low B12 levels Take medications like antacids or metformin Are in a weight loss program Experiencing brain fog or low mood Want to enhance energy before workouts, travel or events Since B12 is water-soluble your body will excrete what it doesnt use, making the injections generally well-tolerated and safe

A.LangmanL.et al (2019)

Most protocols run 6-12 weeks to address acute healing needs