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In biochemical systems, actin-binding peptides derived from thymosin beta-4 function as regulators of cytoskeletal assembly by influencing the equilibrium between monomeric and filamentous actin

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Once within the mitochondria, PGAM5 dephosphorylates AIFM1 at Ser116, ultimately resulting in the induction of oxeiptosis in HeLa cervical cancer cells [74]

The authors also reported that the use of chemotherapy has demonstrated low response rates and yielded no clear mortality benefit in the treatment of MMNST