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Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus
By installing a small, well-defined ring, we can tune how long the drug lasts, how stable it is, and even how it signalsall while staying compatible with the complex structures already in use. Reference: Leader-Independent C-Terminal Modification by a Radical S-Adenosyl-l-methionine Maturase Enables Macrocyclic GLP-1-Like Peptides by Jacob K
Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid
If a sponsor wants to focus on muscle volume assessments, MRI offers more muscle-related endpoints, while DXA can assess fat and lean mass parameters
Further DBPC studies using biomarkers of metabolic pathways related to BH 4 metabolism will be needed to determine which children with ASD will most benefit from formulations of BH 4 supplementation like sapropterin
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