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During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

cruzi epimastigotes incubated in fresh human serum exhibited a decline in T[SH] 2 and GSH levels, decreased mitochondrial aconitase activity, and increased ROS levels (Piacenza et al., 2007)

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