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A review of 12 available trials found a median sample size of just 48 participants and noted that eight of the twelve studies were funded by clinics selling the injections a significant source of bias

In fact, both sulfonylureas and thiazolidinediones are negative predictors for GLP-1 M responsiveness

A better understanding of how T and B-cell responses evolve over time and the signals needed to prolong protective immunity could have an enormous impact across the spectrum of vaccines

In particular, clinical heterogeneity complicates the development of robust clinical endpoints, as small and fragmented patient populations often lack sufficient data to establish reliable outcome measures

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