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Once the cysteine moieties become oxidized, they combine to form cystine

In addition, sorafenib, a kinase inhibitor approved for the treatment of RCC and HCC, inhibits SLC7A11 to suppress the growth of these tumors via the induction of ferroptosis 67,68

Cell uptake of nanoparticles The cellular uptake of nanoparticles was monitored by CLSM

It also enhances the activity of the transcription factor Nrf2, which regulates genes crucial for cellular redox homeostasis and safeguarding cells against oxidative damage (Liu Z