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Pay attention to warning signs, especially trouble breathing and severe weakness

Briefly, the preproglucagon gene undergoes tissue-specific post-translational modification with the help of specific propeptidase convertase (PC1/3) to produce two variants of GLP-1, the amidated GLP-1 [736], and the glycine-extended GLP-1 [737] in the ileum and hypothalamus (Lafferty et al., 2021

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Temporary alcohol avoidance during dose escalation may be prudent, as gastrointestinal side effects are most common during this phase