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Mice with a homozygous deletion of the Rag-2 alleles completely lack NK-like T, T and B cells and have increased incidence and growth of spontaneous tumors and chemically induced cancer lesions (77)

3,27 A heavy emphasis on weight loss as a treatment strategy combined with difficulty losing weight may also contribute to the higher prevalence of eating disorders seen particularly in adolescents with PCOS, thus, a weight neutral approach may be better for addressing women with PCOS who experience psychological issues