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Shan et al., 2018)

This hypothesis is supported by emerging data but has not been definitively confirmed in large trials

doi: 10.1038/nrgastro.2017.88

Abstract 518: Erk5 S496 phosphorylation, but not Erk5 kinase or transcriptional activity, is responsible for promoting macrophage inflammation and mitochondrial dysfunction via upregulating novel site of Nrf2 K518 sumoylation