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Exogenous factors, including various pollutants, could further increase extracellular GSSG, perhaps limiting the export of GSSG against a concentration gradient

At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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These include [6, 34, 39]: Irritation at the site of injection Fatigue Nausea Light-headedness Sweatin g Adverse effects are often attributable to low-grade peptides