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Thrombotic events were monitored throughout the clinical programme and did not demonstrate a significant increase compared to placebo or active comparators

the 20% threshold was not part of the statistical testing hierarchy) Among the participants for whom data were available at the week 68 visit (1212 participants in the semaglutide group and 577 in the placebo group), these thresholds were reached by 86.4% (1047 participants), 69.1% (838 participants), 50.5% (612 participants), and 32.0% (388 participants), respectively, in the semaglutide group, as compared with 31.5% (182 participants), 12.0% (69 participants), 4.9% (28 participants) Participants who received semaglutide had a greater improvement with respect to cardiometabolic risk factors and a greater increase in participant-reported physical functioning from baseline than those who received placebo

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Mental Health 3 , 354373 (2025)

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