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Mol Cell Biol 24:66906700

Some large analyses report lower rates of myocardial infarction, stroke, and all-cause mortality with tirzepatide compared with GLP-1 receptor agonists, including semaglutide ( Methodological limitations of comparative data Several methodological limitations complicate direct comparisons between these agents

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The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo treated groups approximately 3 to 4 kg) and perhaps slightly less than that of phentermine-topiramate