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doi: 10.1074/jbc.M207217200

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Furthermore, PGC-1 suppresses the transport of NF-B p65 from the cytoplasm to the nucleus and the degradation of IB by regulating NF-B, thereby reducing A-induced neuronal death and inhibiting neuroinflammation, which in turn reduces mitochondrial damage and restores AD cognitive deficits (Zhang Y

Combined with Vitamin C, it inhibits melanin production, leading to a brighter and more even complexion

This dynamic self-optimization of ligand stoichiometry enables precise tuning for maximal degradation efficacy