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10.3389/fimmu.2023.1192506 84 LiL.CuiN.HaoT.ZouJ.JiaoW.YiK.et al (2021)

Plant Physiol 134:595604

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PMID: 30575801

Interestingly, frameshift mutations disrupting the C-terminal DNA binding interface of PDS5B (c.3939dup and c.3954del) have been identified in gastrointestinal cancers 37 , underscoring the possible significance of the PDS5B DNA binding attribute in tumor suppression, and indicating that cancers harboring PDS5B mutations could be targeted with PARP inhibitors 38