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Ethical approval The study was approved by the Institutional Review Board for Clinical Research Committee (IRB) of Mansoura University with the approval code R.22.10.1897.R1 and with the IRB committee, Al Yousif Hospital, Alkhobar, Saudi Arabia, (AYH IRB: 02/03/2023)

Details of each are described below

Andreeff, M, Tafuri A, Bettelheim P, Valent P, Estey E, Lemoli R, Goodacre A, Clarkson B, Mandelli F, Deisseroth A

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The results indicated that at 52 weeks, the weight reduction effects of mono-agonists, dual-agonists, and triple-agonists were 7.03 kg, 11.07 kg, and 24.15 kg, respectively