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Tier 3 (BMI 35-39.9 with comorbidities or BMI 40+): Aggressive pharmacotherapy with GLP-1 agonists or dual agonists, potentially combined with very low-calorie dietary interventions and consideration of bariatric surgery referral if medical management is insufficient

Cartwright MJ, Tchkonia T, Kirkland JL

Always consult your GP before starting any supplement regimen, particularly if you have existing medical conditions or take prescription medications

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