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Key Takeaways Tesamorelin is FDA-approved: it is the only GHRH analog with an approved indication for visceral fat reduction, giving it one of the best-documented clinical safety profiles among peptides

By blocking NF-B, it reduces the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO) in keratinocytes and dermal cells

This creates pressure that can damage the optic nerve

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Nanoencapsulation can shield bioactives from light, heat, oxidation, and pH extremes