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Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration ( Accompanying inflammation and mechanical damage, oxidative stress and multiple forms of cell death are deeply involved in the molecular mechanisms driving OA progression ( Figure 1 )

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Visual observation suggested a pattern where the plaques in saline-treated mice were generally larger and more densely stained compared to the plaques in GHKCu-treated cohorts (Figure 3)

Sirtuins are a family of enzymes that deacetylate proteins , removing acetyl groups from lysines on histones (which regulates gene expression) and on other proteins (which regulates metabolism and stress response)