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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

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A recent study used equal analgesic doses of morphine and methadone and found less tolerance was induced with methadone (Enquist et al., 2012), but methadone is also an N -methyl-d-aspartate (NMDA) receptor antagonist (although at very high concentrations, Matsui and Williams 2010)