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Clin Nutr 2017;36(3):672679

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The question nobody wants to ask: Will I regain weight if I stop? Many people do regain some weight if they discontinue, because obesity is a chronic metabolic condition, and the appetite/biological drivers can return

IGF-1 LR3 functions as a potent, long-acting agonist of the IGF-1 Receptor (IGF-1R) , activating key intracellular signaling pathways, primarily the PI3K Akt and MAPK pathways