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27 Our study indicated that the expression of ABHD6 in the T2DM+NAFLD group was significantly higher than that in the control group, and Semaglutide treatment could significantly reduce the expression of ABHD6 in the liver of T2DM+NAFLD mice

Some patients may need dose adjustments during significant weight reduction

The entire process takes about 15 minutes to get started

The trade-off involves potentially more pronounced GI side effects during titration

Available pen strengths deliver weekly doses typically titrated from 0.25 mg to 0.5 mg, with maintenance doses of 1 mg or 2 mg based on response and tolerability