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These findings established that epilepsy patients exhibit systemic and central inflammatory activation (Kanemura, 2024

Nave CD4+ and CD8+ T cells activated by antigen-presenting dendritic cells within lymph nodes migrate along increasing S1P gradients from lymphoid tissues (low S1P) to circulation (high S1P) via S1PR1 signaling

A 2025 systematic review found that 35 of 36 BPC-157 studies were conducted in rodents, and the single human study was a small, uncontrolled retrospective analysis of 12 individuals

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