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In terms of overall business developments, the single biggest update from Lilly's latest report is that the FDA approved Foundayo as the first oral GLP-1 agonist for obesity that can be taken at any time of day and without any restrictions related to food or water

Morning or evening does not appear to matter significantly, though consistency in timing helps establish a routine

There isnt a head to head study, but when looking at similarly designed placebo controlled studies Retatrutide doubles the weight loss efficacy of Semaglutide and its about 50% better than Tirzepatide

10.3390/antiox7050063 Antioxidants

Drugs from the GLP-1RA group targeting the GLP-1R, reduce damage caused by hypoperfusion through the interaction of pleiotropic pathways and signaling cascades, including those involved in mutual regulation of the gut and brain, thereby opening up new prospects for the treatment of neurocognitive disorders