Most patients report early changes in sleep quality and recovery within 24 weeks
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Because GLP-1 therapy is titrated and monitored over months, the recurring fee funds the clinical oversight around the drug, not simply the drug itself
Beyond its role in serotonin synthesis, tryptophan plays a central role in the kynurenine pathway, a metabolic pathway critical for the production of nicotinamide adenine dinucleotide (NAD+), a molecule essential for ATP generation in cellular metabolism (Savitz, 2020) (Figure 5)
The use of DPP-4is as a comparator provided a highly comparable control group, particularly as both drugs were used in the setting of sole add-on medication to metformin, and both drugs have similar priority in the management of T2D