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In a highdose semaglutide trial (7.2 mg weekly), participants lost about 20.7% of body weight in 72 weeks, with a substantial portion achieving up to 25% weight loss

J Bone Miner Res 35:430439 [DOI] [PMC free article] [PubMed] [Google Scholar] 31.Pines A (2012) Weight loss, weight regain and bone health

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Conducted in artificial cell lines, the findings did not address the key question as to whether the truncated form of GLP-1 located in the gut activated the pancreas to release insulin in the way incretin was presumed to work

Additionally, companies are focusing on differentiating weight loss results in terms of muscle versus fat loss, with those showing minimal muscle loss likely to outperform