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Multicenter randomized phase II study comparing docetaxel plus curcumin versus docetaxel plus placebo in firstline treatment of metastatic castrationresistant

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The proposed mechanism centers on modulation of the nitric oxide system: BPC-157 counteracts L-NAME-induced eNOS blockade in rat models and supports vascular sprouting through VEGFR2 internalization (Hsieh et al., J Mol Med , 2017)