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A Cardiorespiratory Digital Twin can ingest wearable data (heart-rate variability, sleep architecture, training load), biomarker data (inflammatory markers, MOTS-c levels, collagen-turnover markers), and genomic data (connective-tissue gene variants, mitochondrial DNA haplogroup) to create a continuously updated model of an individual athletes physiological state

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10.1155/2017/1480294 91 JoladS

The peptides were eluted onto an EASY-Spray HPLC column (Thermo ES902, ES903) using an Acclaim PepMap 100 (Thermo 164535) loading column and separated at a flow rate of 0.25 L/min

However, in adult life, SIRT1 is expressed mainly in the hippocampus and cerebral cortex (Sasaki and Kitamura 2010)