long term glp 1 use REPEATED GLP-1 MAY PROMOTE WEIGHT GAIN: A new mice study found exactly that. Repeated cycles of GLP-1's may have long term adverse effects on the very thing they were GLP-1 Medications for Weight Loss:

The metabolic responsiveness you used to take for granted has quietly faded, and no amount of discipline seems to fully bring it back

Similarly, providing a mixed antioxidant supplement to exercising 2-yr-old Thoroughbreds reduced baseline and attenuated post-exercise increases in mRNA expression of pro-inflammatory cytokines, TNF and IL-1 (Horohov et al., 2012)

In females specifically, IN delivery suppressed PI3K-AKT-mTOR signaling (FDR = 0.062)

MT1/2 expression is notably enhanced by zinc therapy in both PC-3 and BPH cells, coincident with the restoration of intracellular zinc concentrations

Zonulin What it measures: Intestinal permeability aka "leaky gut." Zonulin is a protein that regulates the tight junctions between gut lining cells