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Krentz AJ, Fujioka K, Hompesch M

doi: 10.3390/biom11020153 94 MengYSandowJJCzabotarPEMurphyJM

It is unclear whether GIPR agonism enhances weight loss because GIP itself does not affect food intake or energy expenditure, GIPR antagonists induce weight loss in mice and non-human primates (9), and tirzepatide does not cause weight loss in obese Glp1r / mice (10)