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ROS produced by acute pancreatitis stimulate NF-B, leading to excessive release of cytokines such as interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-18 (IL-18), interleukin-6 (IL-6), and TNF- [81]

This slow, controlled absorption supports consistent peptide delivery to the bloodstream, promoting more stable and sustained effects compared to injections or oral forms

[118] reported that intranasal azelastine and mometasone reduced IL-4, GATA-3, and RORt expression and the tissue eosinophil count and increased Foxp3 expression in Dermatophagoides farinae (Derf)-induced AR mice

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While no specific harm has been documented, the absence of research means risks cannot be adequately assessed