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(microbial response, gene expression and element accumulation)

Weeks 13 onward: 12mg once weekly (maximum studied dose)

This study was part of a call to action for more diverse images in textbooks

The SURMOUNT-5 head-to-head comparison trial provided definitive evidence of tirzepatide's superiority over semaglutide, with Zepbound producing 20.2% average weight loss compared to 13.7% for Wegovy, a 47% greater relative reduction

Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)